Invited speakers
- Lai Guan Ng (Shanghai, China) - Keynote speaker
- Borko Amulic (Bristol, UK)
- Sergio Catz (La Jolla, USA)
- Raphaela Goldbach-Mansky (Bethesda, USA)
- Anna Huttenlocher (Madison, USA)
- Tanya Mayadas (Boston, USA)
- Mia Phillipson (Uppsala, Sweden)
- Christoph Scheiermann (Geneva, Switzerland)
- Oliver Soehnlein (Muenster, Germany)
- Markus Sperandio (Munich, Germany)
- Marjolein van Egmond (Amsterdam, The Netherlands)
- Veronique Witko-Sarsat (Paris, France)
Detailed program
Day 1 – Wednesday, 20 March 2024
| 15:00-18:00 | Registration | |
| 17:30-17:45 | Opening address Attila Mócsai |
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| Keynote session
Chairs: Tamás Németh, Balázs Enyedi |
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| 17:45-19:00 |
Lai Guan Ng (Shanghai, China) Neutrophils: The Power of More Than One |
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| 19:00-21:00 | Welcome reception | |
Day 2 – Thursday, 21 March 2024
| Cell regulation and migration
Chairs: Annemarie Meijer, Árpád Lányi |
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| 8:30-9:00 | Sergio Catz (La Jolla, USA) The endolysosome, a sensor for the regulation of phagocyte function | |
| 9:00-9:15 | O-01Matteo Napoli (Munich, Germany) Cytosolic S100A8/A9 promotes Ca2+ supply at LFA-1 adhesion clusters during neutrophil recruitment | |
| 9:15-9:30 | O-02Sabino Garra (Bari, Italy) Selective inhibition of two aquaporin membrane channels, AQP3 or AQP9, impairs human PBMCs and neutrophil cell migration | |
| 9:30-9:45 | O-03Markus Rehberg (Neuherberg, Germany) Alveolar macrophages initiate the spatially restricted neutrophil recruitment during nanoparticle inhalation. | |
| 9:45-10:00 | O-04Nils Olijhoek (Sheffield, UK) In The Eye Of The Swarm - Unravelling Neutrophil Swarming Dynamics In Danio rerio | |
| 10:00-10:30 | Coffee break | |
| Novel techniques and cell trafficking Chairs: Steve Renshaw, Giuseppe Calamita | ||
| 10:30-11:00 | Anna Huttenlocher (Madison, United States) Engineering human iPSC derived neutrophils to understand anti-fungal defense | |
| 11:00-11:15 | O-05Áron Pánczél (Budapest, Hungary) Genetic editing of HoxB8 cells to study neutrophil functions in vivo | |
| 11:15-11:30 | O-06Boldizsár Vámosi (Budapest, Hungary) Developing next-generation LTB4 biosensors with a high-throughput molecular pipeline | |
| 11:30-11:45 | O-07Loïc Rolas (London, UK) Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues | |
| 11:45-12:00 | O-08Sonja Vermeren (Edinburgh, UK) A pathway preventing excessive formylated peptide-induced inflammation-associated microvascular leakage | |
| 12:00-12:30 | Group photo | |
| 12:30-14:00 | Lunch break | |
| Phagocytes in diseases I. Chairs: Ulla Knaus, Ádám Dénes | ||
| 14:00-14:30 | Raphaela Goldbach-Mansky (Bethesda, USA) When misspellings provide new insights: ... lessons from patients with rare autoinflammatory diseases | |
| 14:30-14:45 | O-09Krisztina Futosi (Budapest, Hungary) Tyrosine phosphorylation pathway in monosodium urate crystal-induced inflammation | |
| 14:45-15:00 | O-10Mareike Neumann (Lübeck, Germany) Metabolic intervention with 2-DG ameliorates symptoms in a model of atopic dermatitis | |
| 15:00-15:15 | O-11Eszter Kaposztas (Budapest, Hungary) The effect of entospletinib in autoantibody-induced experimental arthritis | |
| 15:15-15:30 | O-12Hannah Wiggett (Saclay, France) Illuminating antiviral inflammation and neuroinflammation | |
| 15:30-16:00 | Coffee break | |
| Phagocytes in diseases II. Chairs: Daniela Maier-Begandt, Attila Gácser | ||
| 16:00-16:30 | Oliver Soehnlein (Muenster, Germany) New concepts of neutrophil maturation - a matter of location | |
| 16:30-16:45 | O-13Sofia de Oliveira (Bronx, USA) Metabolic syndrome impacts neutrophil biology and their role in disease | |
| 16:45-17:00 | O-14Beata Goldyn (Bonn, Germany) Unveiling the significance of IL-22: Exploring healing and recurrence in the context of Pyelonephritis | |
| 17:00-17:15 | O-15Julia J. Dielesen (London, UK) Investigating the dynamics and characteristics of neutrophils infiltrating the draining lymph nodes post Ischaemia-Reperfusion Injury, and their role in regulating CD4+ T-cells | |
| 17:15-17:30 | O-16Roland Immler (Planegg-Martinsried, Germany) PreImplantation factor (PIF) is a critical modulator of neutrophil functions during pregnancy | |
| 17:30-17:45 | O-17Éva Kemecsei (Budapest, Hungary) Characterization of the role of lymphatics in autoimmune arthritis | |
| 18:30-20:30 | Poster Dinner | |
Day 3 – Friday, 22 March 2024
| Neutrophil development and plasticity
Chairs: Jesmond Dalli, Carlos Silvestre-Roig |
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| 8:30-9:00 | Markus Sperandio (Munich, Germany) Ontogenetic regulation of neutrophil function | |
| 9:00-9:15 | O-18Steven D.S. Webbers (Amsterdam, The Netherlands) Towards culturing the perfect neutrophil: Functional and proteogenomic comparison of stem cell derived neutrophils versus circulating neutrophils | |
| 9:15-9:30 | O-19Daniela Maier-Begandt (Planegg-Martinsried, Germany) VPS18 is essential for proper neutrophil development | |
| 9:30-9:45 | O-20Abhinandan Deva Prasad (Oxford, UK) Novel transcriptional regulators of neutrophil maturation | |
| 9:45-10:00 | O-21Ulla Knaus (Dublin, Ireland) Neutrophil plasticity opens the ROS treasure chest | |
| 10:00-10:30 | Coffee break | |
| Antitumor activity and host defense Chairs: Sarah Walmsley, Nicholas Lukacs | ||
| 10:30-11:00 | Tanya Mayadas (Boston, USA) Harnessing neutrophils for T cell dependent anti-tumor immunity | |
| 11:00-11:15 | O-22Benedict Boateng Antuamwine (Essen, Germany) Exploring neutrophil antitumor functions | |
| 11:15-11:30 | O-23Dennis Gout (Amsterdam, The Netherlands) Fusion of TNF-α to an FcαRI bispecific antibody potentiates neutrophil-mediated anti-tumor effects | |
| 11:30-11:45 | O-24Collins Osei-Sarpong (Münster, Germany) Hepatic neutrophil extracellular traps limit dissemination of gut-derived products | |
| 11:45-12:00 | O-25Liz Hernández (Montpellier, France) In vivo analysis of the contribution of zebrafish S100A10a and S100A10b alarmins to innate immune functions | |
| 12:00-12:30 | Christoph Scheiermann (Geneva, Switzerland) Circadian trafficking and function of dendritic cells and neutrophils | |
| 12:30-14:00 | Lunch break | |
| Macrophages Chairs: Kitti Pázmándi, Mathieu-Benoit Voisin | ||
| 14:00-14:30 | Mia Phillipson (Uppsala, Sweden) The role of macrophages during tissue restoration following injury | |
| 14:30-14:45 | O-26Jesmond Dalli (London, UK) Apoptotic cell uptake triggers localized MCTR production by macrophages to drive efferocytosis and tissue repair | |
| 14:45-15:00 | O-27Hala Ahmad (Debrecen, Hungary) ATRA differently modifies inflammatory response in the various human macrohage subpopulations | |
| 15:00-15:15 | O-28Tobias Stoeger (Munich/Neuherberg, Germany) Macrophage dynamics during nanoparticle triggered lung inflammation revealed by single cell transcriptomics in mice | |
| 15:15-15:30 | O-29Resul Ozbilgic (Montpellier, France) Exploring the role of NRROS in macrophage polarization in zebrafish | |
| 15:30-16:00 | Coffee break | |
| Different types of phagocytes Chairs: Balázs Rada, Ákos Lőrincz | ||
| 16:00-16:30 | Marjolein van Egmond (Amsterdam, The Netherlands) IgA-activated phagocytes: innocent until proven quilty? | |
| 16:30-16:45 | O-30Valeria Maria Oliva (Geneva, Switzerland) Control of dendritic cell dynamics in the skin by the sympathetic nervous system | |
| 16:45-17:00 | O-31Zuzana Parackova (Prague, Czech Republic) Unravelling immune dysregulation in STAT1 gain-of-function mutations: Insights from dendritic cells and neutrophils | |
| 17:00-17:15 | O-32Nicholas Lukacs (Ann Arbor, USA) Cellular metabolic regulation of dendritic cell innate immune responses to RSV is mediated via NAD-dependent activation | |
| 17:15-17:30 | O-33Mayra A. Aguirre-García (Leiden, The Netherlands) Lysosomes coordinate innate immunity against intracellular mycobacteria in macrophages via Guanylate-binding protein 1 | |
| 17:30-17:45 | O-34Philip Elks (Sheffield, UK) Tribbles1 activates leukocytes to be host protective during in vivo mycobacterial infection | |
| 18:45-22:00 | Social event with dinner | |
Day 4 – Saturday, 23 March 2024
| Antimicrobial functions I.
Chairs: Sofia de Oliveira, Krisztina Futosi |
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| 8:30-9:00 | Veronique Witko-Sarsat (Paris, France) PCNA as a regulator of neutrophil function in inflammatory diseases | |
| 9:00-9:15 | O-35Lucie Pesenti (Paris, France) Interactome of cytosolic PCNA in neutrophils from patients with covid-19 has uncovered novel protein partners that are associated with disease severity | |
| 9:15-9:30 | O-36Annemarie H. Meijer (Leiden, The Netherlands) DRAM1 promotes autophagy-related host defense mechanisms | |
| 9:30-9:45 | O-37Antonio Monera Girona (El Palmar, Spain) Peds1 deficiency in zebrafish reveals a crucial role for plasmalogens in phagocyte survival, and host inflammatory response and resistance to bacterial infection | |
| 9:45-10:00 | O-38Balazs Rada (Athens, USA) The cystic fibrosis airway environment limits the ability of human neutrophils to kill methicillin-resistant Staphylococcus aureus by several potential mechanisms | |
| 10:00-10:30 | Coffee break | |
| Antimicrobial functions II. Chairs: Szilvia Benkő, Philip Elks | ||
| 10:30-11:00 | Borko Amulic (Bristol, UK) Mitochondrial regulation of pathogenic neutrophil responses in malaria | |
| 11:00-11:15 | O-39David Barinberg (Erlangen, Germany) Chronic disease after Leishmania mexicana infection depends on IL-5-mediated eosinophilia | |
| 11:15-11:30 | O-40Nathan G. F. Leborgne (Mittelhäusern, Switzerland) Neutrophil serine proteases degrade SARS-CoV-2 spike protein and reduce virus replication and inflammation in vivo | |
| 11:30-11:45 | O-41Csaba I. Timár (Budapest, Hungary) Proteolytic products accumulating in the blood plasma of severly septic patients impair neutrophil functions | |
| 11:45-12:00 | O-42Margarida C. Gomes (London, UK) Training innate immunity in zebrafish using Shigella | |
| 12:00-12:30 | Award and Closing remarks | |
| 12:30-14:00 | Lunch | |
| 14:15-18:30 |
INFLANET dissemination satellite meeting Detailed program |
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List of posters
| P-01 | Almke Bader (Planegg-Martinsried, Germany) THEMIS2, a novel negative regulator of β2 integrins in neutrophils | |
| P-02 | Lili Balogh (Budapest, Hungary) The effect of platelet-specific Syk- or PLCγ2-deficiency on synovial fibroblasts in autoimmune arthritis | |
| P-03 | Leonie Behrens (Amsterdam, The Netherlands) Unravelling the mechanism-of-action of the innate immune checkpoint CD47-SIRPα in neutrophil-mediated tumor cell killing | |
| P-04 | Eduárd Bíró (Debrecen, Hungary) Inflammatory effects of SARS-CoV-2 antigens on different human monocyte‐derived macrophage subpopulations | |
| P-05 | Ana Rita Brás (Budapest, Hungary) Role of microglia-endothelial interactions in systemic inflammation-induced vascular and leukocyte responses | |
| P-06 | Florabelle Cabarrubias (Szeged, Hungary) Immunomodulation of Peripheral Blood Mononuclear Cell-Derived Monocytes by Candida Species | |
| P-07 | Ivan Conejeros (Gießen, Germany) Role of AMPK in Besnoitia besnoiti and Toxoplasma gondii tachyzoite-induced PMN responses | |
| P-08 | Maria Cruz Cobo (Genève, Switzerland) Effect of calcium signaling enhancers on dendritic cell antigen cross-presentation | |
| P-09 | Domonkos Czárán (Budapest, Hungary) Lacking ARHGAP25 significantly mitigates the severity of contact hypersensitivity in mice | |
| P-10 | Roberta De Matteis (London, United Kingdom) Resolvin T4 enhances macrophage cholesterol efflux to reduce vascular disease | |
| P-11 | Dorottya Deli (Budapest, Hungary) Analyzing the effect of oral tyrosine kinase inhibitors on basal tyrosine phosphorylation of circulating leukocytes | |
| P-12 | Gizem Duru (Amsterdam, The Netherlands) Targeting and activating tumor endothelial cells to increase intra-tumoral neutrophil infiltration and the efficacy of cancer immunotherapy | |
| P-13 | László Fazekas (Budapest, Hungary) Impaired neutrophil granulocyte wound recruitment in PMCA4 deficient Zebrafish | |
| P-14 | Esteban Gomez Cifuentes (London, United Kingdom) Loss of LGR6 expression as a result of a frameshift mutation alters pro-resolving responses in human phagocytes | |
| P-15 | Daniella Görög (Budapest, Hungary) Quantification of the phagocytic activity of HoxB8 progenitor-derived neutrophil-like cells by flow cytometry | |
| P-16 | Adrienn Gyöngyösi (Debrecen, Hungary) TKS4 protein functions in tumor-associated myeloid cells | |
| P-17 | Dávid Győri (Budapest, Hungary) De novo steroidogenesis in tumor cells drives bone metastasis and osteoclastogenesis | |
| P-18 | Dominik Hanke (Giessen, Germany) Characterization of extracellular traps induced by Toxoplasma gondii tachyzoites in monocytes and macrophages | |
| P-19 | Márk Havasi (Budapest, Hungary) Characterisation of CRISPR-edited neutrophil progenitors | |
| P-20 | Letícia Hudecová (Bratislava, Slovakia) Negative impact of cathelicidin on the vicious cycle of NETs formation | |
| P-21 | Vincent Jaquet (Genève, Switzerland) Identification of small molecule Piezo1 inhibitors | |
| P-22 | Emiliána Jex (Budapest, Hungary) Respiratory burst and in vitro migration of neutrophil-like cells differentiated from CRISPR/Cas9 modified conditionally immortalized myeloid progenitors | |
| P-23 | Nastassia Kabankova (Essen, Germany) HoxB8 Cells as a Tool for Investigating Granulopoiesis during Cancer Progression | |
| P-24 | Petra Koncz (Budapest, Hungary) Investigating the role of tyrosine kinase pathways in experimental autoimmune skin blistering | |
| P-25 | Nedim Kozarac (Mittelhäusern, Switzerland) Neutrophil serine proteases reduce SARS-CoV-2 entry in vitro by degrading the spike protein prior to cell attachment | |
| P-26 | Lukács Lesinszki (Budapest, Hungary) Myeloid Src-family kinases mediate crescentic glomerulonephritis | |
| P-27 | Ákos Lőrincz (Budapest, Hungary) Neutrophil EVs modulate the viability of leukocytes and modulate the inflammation | |
| P-28 | Nóra Majerhoffer (Budapest, Hungary) The effect of synovial fibroblast-specific Syk deletion in a chronic polyarthritis model in mice | |
| P-29 | Yevheniia Minchuk (Bonn, Germany) Heterogeneity in Kupffer cell-mediated killing of S. aureus | |
| P-30 | Veronika Miskolci (Newark, United States) Immunoresponsive gene 1 supports collagen remodeling following sterile injury | |
| P-31 | Venceslas Ngounou (Budapest, Hungary) Cell shape dynamics of phagocytes during phagocytosis | |
| P-32 | Zsuzsanna Papp (Budapest, Hungary) Investigating the role of β2-integrins in in vitro and in vivo inflammatory reactions | |
| P-33 | Csaba Papp (Szeged, Hungary) New BSL-2 in vivo facility at Department of Microbiology at Univesity of Szeged for infectious biology | |
| P-34 | Kitti Pázmándi (Debrecen, Hungary) Homotypic cell-cell interactions through SLAMF receptors facilitate the type I interferon production in human plasmacytoid dendritic cells (pDCs) | |
| P-35 | Annamaria Pedoto (Murcia, Spain) The dynamic interplay between neutrophil and macrophage in a zebrafish model of COVID-19-associated cytokine storm syndrome | |
| P-36 | Tímea Pintér (Budapest, Hungary) Investigation of signaling during phagocytic activity of neutrophils derived from reversibly immortalized progenitors | |
| P-37 | Caroline Pumpe (Edinburgh, United Kingdom) Modulation of Neutrophilc Inflammation in Rheumatoid Arthritis by Altered Antibody Glycosylation | |
| P-38 | Camille Rabesahala de Meritens (Genève, Switzerland) Stim1/2 genetic ablation impairs PLC-dependent Ca2+ signals and neutrophil spreading | |
| P-39 | Luca Sándor (Budapest, Hungary) Genetic deficiency of Syk in platelets promotes solid tumor metastasis | |
| P-40 | Péter Sasvári (Budapest, Hungary) The paradoxical effect of ARHGAP25 in imiquimod-induced mouse psoriasis model | |
| P-41 | Céline Sewnath (Amsterdam, The Netherlands) Neutrophil-mediated tumor cell killing induces uptake of antigens and dendritic cell maturation | |
| P-42 | Fleur van Oosterom (Amsterdam, The Netherlands) Culturing human CD34+ Hematopoietic Stem Cells into mature neutrophils: details matter | |
| P-43 | Simon Vikár (Budapest, Hungary) Inhibition of the classical complement activation pathway blocks skin separation in a granulocyte-mediated human ex vivo model of bullous pemphigoid | |
