Scientific program

Invited speakers

  • Lai Guan Ng (Shanghai, China) - Keynote speaker
  • Borko Amulic (Bristol, UK)
  • Sergio Catz (La Jolla, USA)
  • Raphaela Goldbach-Mansky (Bethesda, USA)
  • Anna Huttenlocher (Madison, USA)
  • Tanya Mayadas (Boston, USA)
  • Mia Phillipson (Uppsala, Sweden)
  • Christoph Scheiermann (Geneva, Switzerland)
  • Oliver Soehnlein (Muenster, Germany)
  • Markus Sperandio (Munich, Germany)
  • Marjolein van Egmond (Amsterdam, The Netherlands)
  • Veronique Witko-Sarsat (Paris, France)

Detailed program

Day 1 – Wednesday, 20 March 2024

15:00-18:00 Registration
17:30-17:45 Opening address
Attila Mócsai
Keynote session
Chairs: Tamás Németh, Balázs Enyedi
17:45-19:00 Lai Guan Ng (Shanghai, China)
Neutrophils: The Power of More Than One

19:00-21:00 Welcome reception

Day 2 – Thursday, 21 March 2024

Cell regulation and migration
Chairs: Annemarie Meijer, Árpád Lányi
8:30-9:00Sergio Catz (La Jolla, USA)
The endolysosome, a sensor for the regulation of phagocyte function
9:00-9:15O-01Matteo Napoli (Munich, Germany)
Cytosolic S100A8/A9 promotes Ca2+ supply at LFA-1 adhesion clusters during neutrophil recruitment
9:15-9:30O-02Sabino Garra (Bari, Italy)
Selective inhibition of two aquaporin membrane channels, AQP3 or AQP9, impairs human PBMCs and neutrophil cell migration
9:30-9:45O-03Markus Rehberg (Neuherberg, Germany)
Alveolar macrophages initiate the spatially restricted neutrophil recruitment during nanoparticle inhalation.
9:45-10:00O-04Nils Olijhoek (Sheffield, UK)
In The Eye Of The Swarm - Unravelling Neutrophil Swarming Dynamics In Danio rerio
10:00-10:30Coffee break
Novel techniques and cell trafficking
Chairs: Steve Renshaw, Giuseppe Calamita
10:30-11:00Anna Huttenlocher (Madison, United States)
Engineering human iPSC derived neutrophils to understand anti-fungal defense
11:00-11:15O-05Áron Pánczél (Budapest, Hungary)
Genetic editing of HoxB8 cells to study neutrophil functions in vivo
11:15-11:30O-06Boldizsár Vámosi (Budapest, Hungary)
Developing next-generation LTB4 biosensors with a high-throughput molecular pipeline
11:30-11:45O-07Loïc Rolas (London, UK)
Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues
11:45-12:00O-08Sonja Vermeren (Edinburgh, UK)
A pathway preventing excessive formylated peptide-induced inflammation-associated microvascular leakage
12:00-12:30Group photo
12:30-14:00Lunch break
Phagocytes in diseases I.
Chairs: Ulla Knaus, Ádám Dénes
14:00-14:30Raphaela Goldbach-Mansky (Bethesda, USA)
When misspellings provide new insights: ... lessons from patients with rare autoinflammatory diseases
14:30-14:45O-09Krisztina Futosi (Budapest, Hungary)
Tyrosine phosphorylation pathway in monosodium urate crystal-induced inflammation
14:45-15:00O-10Mareike Neumann (Lübeck, Germany)
Metabolic intervention with 2-DG ameliorates symptoms in a model of atopic dermatitis
15:00-15:15O-11Eszter Kaposztas (Budapest, Hungary)
The effect of entospletinib in autoantibody-induced experimental arthritis
15:15-15:30O-12Hannah Wiggett (Saclay, France)
Illuminating antiviral inflammation and neuroinflammation
15:30-16:00Coffee break
Phagocytes in diseases II.
Chairs: Daniela Maier-Begandt, Attila Gácser
16:00-16:30Oliver Soehnlein (Muenster, Germany)
New concepts of neutrophil maturation - a matter of location
16:30-16:45O-13Sofia de Oliveira (Bronx, USA)
Metabolic syndrome impacts neutrophil biology and their role in disease
16:45-17:00O-14Beata Goldyn (Bonn, Germany)
Unveiling the significance of IL-22: Exploring healing and recurrence in the context of Pyelonephritis
17:00-17:15O-15Julia J. Dielesen (London, UK)
Investigating the dynamics and characteristics of neutrophils infiltrating the draining lymph nodes post Ischaemia-Reperfusion Injury, and their role in regulating CD4+ T-cells
17:15-17:30O-16Roland Immler (Planegg-Martinsried, Germany)
PreImplantation factor (PIF) is a critical modulator of neutrophil functions during pregnancy
17:30-17:45O-17Éva Kemecsei (Budapest, Hungary)
Characterization of the role of lymphatics in autoimmune arthritis
18:30-20:30 Poster Dinner

Day 3 – Friday, 22 March 2024

Neutrophil development and plasticity
Chairs: Jesmond Dalli, Carlos Silvestre-Roig
8:30-9:00Markus Sperandio (Munich, Germany)
Ontogenetic regulation of neutrophil function
9:00-9:15O-18Steven D.S. Webbers (Amsterdam, The Netherlands)
Towards culturing the perfect neutrophil: Functional and proteogenomic comparison of stem cell derived neutrophils versus circulating neutrophils
9:15-9:30O-19Daniela Maier-Begandt (Planegg-Martinsried, Germany)
VPS18 is essential for proper neutrophil development
9:30-9:45O-20Abhinandan Deva Prasad (Oxford, UK)
Novel transcriptional regulators of neutrophil maturation
9:45-10:00O-21Ulla Knaus (Dublin, Ireland)
Neutrophil plasticity opens the ROS treasure chest
10:00-10:30Coffee break
Antitumor activity and host defense
Chairs: Sarah Walmsley, Nicholas Lukacs
10:30-11:00Tanya Mayadas (Boston, USA)
Harnessing neutrophils for T cell dependent anti-tumor immunity
11:00-11:15O-22Benedict Boateng Antuamwine (Essen, Germany)
Exploring neutrophil antitumor functions
11:15-11:30O-23Dennis Gout (Amsterdam, The Netherlands)
Fusion of TNF-α to an FcαRI bispecific antibody potentiates neutrophil-mediated anti-tumor effects
11:30-11:45O-24Collins Osei-Sarpong (Münster, Germany)
Hepatic neutrophil extracellular traps limit dissemination of gut-derived products
11:45-12:00O-25Liz Hernández (Montpellier, France)
In vivo analysis of the contribution of zebrafish S100A10a and S100A10b alarmins to innate immune functions
12:00-12:30Christoph Scheiermann (Geneva, Switzerland)
Circadian trafficking and function of dendritic cells and neutrophils
12:30-14:00Lunch break
Chairs: Kitti Pázmándi, Mathieu-Benoit Voisin
14:00-14:30Mia Phillipson (Uppsala, Sweden)
The role of macrophages during tissue restoration following injury
14:30-14:45O-26Jesmond Dalli (London, UK)
Apoptotic cell uptake triggers localized MCTR production by macrophages to drive efferocytosis and tissue repair
14:45-15:00O-27Hala Ahmad (Debrecen, Hungary)
ATRA differently modifies inflammatory response in the various human macrohage subpopulations
15:00-15:15O-28Tobias Stoeger (Munich/Neuherberg, Germany)
Macrophage dynamics during nanoparticle triggered lung inflammation revealed by single cell transcriptomics in mice
15:15-15:30O-29Resul Ozbilgic (Montpellier, France)
Exploring the role of NRROS in macrophage polarization in zebrafish
15:30-16:00Coffee break
Different types of phagocytes
Chairs: Balázs Rada, Ákos Lőrincz
16:00-16:30Marjolein van Egmond (Amsterdam, The Netherlands)
IgA-activated phagocytes: innocent until proven quilty?
16:30-16:45O-30Valeria Maria Oliva (Geneva, Switzerland)
Control of dendritic cell dynamics in the skin by the sympathetic nervous system
16:45-17:00O-31Zuzana Parackova (Prague, Czech Republic)
Unravelling immune dysregulation in STAT1 gain-of-function mutations: Insights from dendritic cells and neutrophils
17:00-17:15O-32Nicholas Lukacs (Ann Arbor, USA)
Cellular metabolic regulation of dendritic cell innate immune responses to RSV is mediated via NAD-dependent activation
17:15-17:30O-33Mayra A. Aguirre-García (Leiden, The Netherlands)
Lysosomes coordinate innate immunity against intracellular mycobacteria in macrophages via Guanylate-binding protein 1
17:30-17:45O-34Philip Elks (Sheffield, UK)
Tribbles1 activates leukocytes to be host protective during in vivo mycobacterial infection
18:45-22:00 Social event with dinner

Day 4 – Saturday, 23 March 2024

Antimicrobial functions I.
Chairs: Sofia de Oliveira, Krisztina Futosi
8:30-9:00Veronique Witko-Sarsat (Paris, France)
PCNA as a regulator of neutrophil function in inflammatory diseases
9:00-9:15O-35Lucie Pesenti (Paris, France)
Interactome of cytosolic PCNA in neutrophils from patients with covid-19 has uncovered novel protein partners that are associated with disease severity
9:15-9:30O-36Annemarie H. Meijer (Leiden, The Netherlands)
DRAM1 promotes autophagy-related host defense mechanisms
9:30-9:45O-37Antonio Monera Girona (El Palmar, Spain)
Peds1 deficiency in zebrafish reveals a crucial role for plasmalogens in phagocyte survival, and host inflammatory response and resistance to bacterial infection
9:45-10:00O-38Balazs Rada (Athens, USA)
The cystic fibrosis airway environment limits the ability of human neutrophils to kill methicillin-resistant Staphylococcus aureus by several potential mechanisms
10:00-10:30Coffee break
Antimicrobial functions II.
Chairs: Szilvia Benkő, Philip Elks
10:30-11:00Borko Amulic (Bristol, UK)
Mitochondrial regulation of pathogenic neutrophil responses in malaria
11:00-11:15O-39David Barinberg (Erlangen, Germany)
Chronic disease after Leishmania mexicana infection depends on IL-5-mediated eosinophilia
11:15-11:30O-40Nathan G. F. Leborgne (Mittelhäusern, Switzerland)
Neutrophil serine proteases degrade SARS-CoV-2 spike protein and reduce virus replication and inflammation in vivo
11:30-11:45O-41Csaba I. Timár (Budapest, Hungary)
Proteolytic products accumulating in the blood plasma of severly septic patients impair neutrophil functions
11:45-12:00O-42Margarida C. Gomes (London, UK)
Training innate immunity in zebrafish using Shigella
12:00-12:30 Award and Closing remarks
14:15-18:30 INFLANET dissemination satellite meeting
Detailed program


List of posters

P-01Almke Bader (Planegg-Martinsried, Germany)
THEMIS2, a novel negative regulator of β2 integrins in neutrophils
P-02Lili Balogh (Budapest, Hungary)
The effect of platelet-specific Syk- or PLCγ2-deficiency on synovial fibroblasts in autoimmune arthritis
P-03Leonie Behrens (Amsterdam, The Netherlands)
Unravelling the mechanism-of-action of the innate immune checkpoint CD47-SIRPα in neutrophil-mediated tumor cell killing
P-04Eduárd Bíró (Debrecen, Hungary)
Inflammatory effects of SARS-CoV-2 antigens on different human monocyte‐derived macrophage subpopulations
P-05Ana Rita Brás (Budapest, Hungary)
Role of microglia-endothelial interactions in systemic inflammation-induced vascular and leukocyte responses
P-06Florabelle Cabarrubias (Szeged, Hungary)
Immunomodulation of Peripheral Blood Mononuclear Cell-Derived Monocytes by Candida Species
P-07Ivan Conejeros (Gießen, Germany)
Role of AMPK in Besnoitia besnoiti and Toxoplasma gondii tachyzoite-induced PMN responses
P-08Maria Cruz Cobo (Genève, Switzerland)
Effect of calcium signaling enhancers on dendritic cell antigen cross-presentation
P-09Domonkos Czárán (Budapest, Hungary)
Lacking ARHGAP25 significantly mitigates the severity of contact hypersensitivity in mice
P-10Roberta De Matteis (London, United Kingdom)
Resolvin T4 enhances macrophage cholesterol efflux to reduce vascular disease
P-11Dorottya Deli (Budapest, Hungary)
Analyzing the effect of oral tyrosine kinase inhibitors on basal tyrosine phosphorylation of circulating leukocytes
P-12Gizem Duru (Amsterdam, The Netherlands)
Targeting and activating tumor endothelial cells to increase intra-tumoral neutrophil infiltration and the efficacy of cancer immunotherapy
P-13László Fazekas (Budapest, Hungary)
Impaired neutrophil granulocyte wound recruitment in PMCA4 deficient Zebrafish
P-14Esteban Gomez Cifuentes (London, United Kingdom)
Loss of LGR6 expression as a result of a frameshift mutation alters pro-resolving responses in human phagocytes
P-15Daniella Görög (Budapest, Hungary)
Quantification of the phagocytic activity of HoxB8 progenitor-derived neutrophil-like cells by flow cytometry
P-16Adrienn Gyöngyösi (Debrecen, Hungary)
TKS4 protein functions in tumor-associated myeloid cells
P-17Dávid Győri (Budapest, Hungary)
De novo steroidogenesis in tumor cells drives bone metastasis and osteoclastogenesis
P-18Dominik Hanke (Giessen, Germany)
Characterization of extracellular traps induced by Toxoplasma gondii tachyzoites in monocytes and macrophages
P-19Márk Havasi (Budapest, Hungary)
Characterisation of CRISPR-edited neutrophil progenitors
P-20Letícia Hudecová (Bratislava, Slovakia)
Negative impact of cathelicidin on the vicious cycle of NETs formation
P-21Vincent Jaquet (Genève, Switzerland)
Identification of small molecule Piezo1 inhibitors
P-22Emiliána Jex (Budapest, Hungary)
Respiratory burst and in vitro migration of neutrophil-like cells differentiated from CRISPR/Cas9 modified conditionally immortalized myeloid progenitors
P-23Nastassia Kabankova (Essen, Germany)
HoxB8 Cells as a Tool for Investigating Granulopoiesis during Cancer Progression
P-24Petra Koncz (Budapest, Hungary)
Investigating the role of tyrosine kinase pathways in experimental autoimmune skin blistering
P-25Nedim Kozarac (Mittelhäusern, Switzerland)
Neutrophil serine proteases reduce SARS-CoV-2 entry in vitro by degrading the spike protein prior to cell attachment
P-26Lukács Lesinszki (Budapest, Hungary)
Myeloid Src-family kinases mediate crescentic glomerulonephritis
P-27Ákos Lőrincz (Budapest, Hungary)
Neutrophil EVs modulate the viability of leukocytes and modulate the inflammation
P-28Nóra Majerhoffer (Budapest, Hungary)
The effect of synovial fibroblast-specific Syk deletion in a chronic polyarthritis model in mice
P-29Yevheniia Minchuk (Bonn, Germany)
Heterogeneity in Kupffer cell-mediated killing of S. aureus
P-30Veronika Miskolci (Newark, United States)
Immunoresponsive gene 1 supports collagen remodeling following sterile injury
P-31Venceslas Ngounou (Budapest, Hungary)
Cell shape dynamics of phagocytes during phagocytosis
P-32Zsuzsanna Papp (Budapest, Hungary)
Investigating the role of β2-integrins in in vitro and in vivo inflammatory reactions
P-33Csaba Papp (Szeged, Hungary)
New BSL-2 in vivo facility at Department of Microbiology at Univesity of Szeged for infectious biology
P-34Kitti Pázmándi (Debrecen, Hungary)
Homotypic cell-cell interactions through SLAMF receptors facilitate the type I interferon production in human plasmacytoid dendritic cells (pDCs)
P-35Annamaria Pedoto (Murcia, Spain)
The dynamic interplay between neutrophil and macrophage in a zebrafish model of COVID-19-associated cytokine storm syndrome
P-36Tímea Pintér (Budapest, Hungary)
Investigation of signaling during phagocytic activity of neutrophils derived from reversibly immortalized progenitors
P-37Caroline Pumpe (Edinburgh, United Kingdom)
Modulation of Neutrophilc Inflammation in Rheumatoid Arthritis by Altered Antibody Glycosylation
P-38Camille Rabesahala de Meritens (Genève, Switzerland)
Stim1/2 genetic ablation impairs PLC-dependent Ca2+ signals and neutrophil spreading
P-39Luca Sándor (Budapest, Hungary)
Genetic deficiency of Syk in platelets promotes solid tumor metastasis
P-40Péter Sasvári (Budapest, Hungary)
The paradoxical effect of ARHGAP25 in imiquimod-induced mouse psoriasis model
P-41Céline Sewnath (Amsterdam, The Netherlands)
Neutrophil-mediated tumor cell killing induces uptake of antigens and dendritic cell maturation
P-42Fleur van Oosterom (Amsterdam, The Netherlands)
Culturing human CD34+ Hematopoietic Stem Cells into mature neutrophils: details matter
P-43Simon Vikár (Budapest, Hungary)
Inhibition of the classical complement activation pathway blocks skin separation in a granulocyte-mediated human ex vivo model of bullous pemphigoid